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 Table of Contents  
Year : 2014  |  Volume : 34  |  Issue : 1  |  Page : 49-51

Nontyphoidal Salmonellosis presented as a parotid abscess within a Warthin's tumor: Case report and review of literature

1 Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
2 Department of Otolaryngology, Head and Neck Surgery, Cheng Ching Hospital, Taichung, Taiwan, Republic of China

Date of Submission06-May-2013
Date of Decision17-Jun-2013
Date of Acceptance04-Jun-2013
Date of Web Publication26-Mar-2014

Correspondence Address:
Kuo-Ping Chang
Department of Otolaryngology, Head and Neck surgery, Kaohsiung Veterans General Hospital, No. 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan
Republic of China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1011-4564.129395

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Most suppurative parotid abscesses are caused by bacterial infection via the Stensen's duct. Formation of a unilateral parotid abscess secondary to Salmonella enterocolitis seldom occurs, and cases arising in the setting of a previous existing parotid tumor have rarely been described to date. This study presents a 71-year-old male patient having a parotid abscess. This was caused by Salmonella enterica serovar Enteritidis (S. enteritidis) in an apparently immunocompetent adult with an inherent parotid tumor. The pathology is consistent with a Warthin's tumor with infarction. By integrating surgical and antimicrobial drug therapy, the disease responded well to treatment. Despite an increasing incidence of extraintestinal salmonellosis in the past decades, a clinical practitioner must maintain a high index of suspicion for rare locations, such as the parotid gland, after uncomplicated bacteremia accompanying enterocolitis. Early diagnosis and prompt treatment are necessary for the prevention of lethal complications.

Keywords: Parotid abscess, nontyphoidal Salmonella, Salmonella enteritidis, Warthin′s tumor

How to cite this article:
Lin YH, Chang KP, Chu ST. Nontyphoidal Salmonellosis presented as a parotid abscess within a Warthin's tumor: Case report and review of literature. J Med Sci 2014;34:49-51

How to cite this URL:
Lin YH, Chang KP, Chu ST. Nontyphoidal Salmonellosis presented as a parotid abscess within a Warthin's tumor: Case report and review of literature. J Med Sci [serial online] 2014 [cited 2020 Aug 8];34:49-51. Available from: http://www.jmedscindmc.com/text.asp?2014/34/1/49/129395

  Introduction Top

Among the major salivary glands, the parotid gland is much more susceptible, relative to the submandibular and sublingual glands, due to its serous secretion, which is devoid of antibodies, lysosomes, and mucins. The predisposing factors may include dehydration, debilitation, and sialoliths with obstruction, which are usually bacterial in nature and may be complicated with abscess formation. The common pathogens are Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Alpha-hemolytic streptococci, and anaerobic bacteria not otherwise specified. [1] The efficient therapeutic strategies include surgical debridement plus adequate use of antibiotics. To the best of our knowledge, there are scanty reports about parotid nontyphoidal salmonellosis. Extraintestinal presentation within an inherent parotid tumor is extremely rare. Herein, a case is presented and the related English literature is reviewed.

  Case Report Top

A 71-year-old male patient, working as a construction worker, had a history of a slow-growing right infra-auricular tumor mass, for 10 years. One week before admission he had an episode of non-bloody watery diarrhea, nausea, and vomiting that lasted for three days. Four days later, he complained of severe right cheek pain over an inherent tumor. His medical history is unremarkable for not taking corticosteroid, diabetes mellitus, autoimmune disease, malignancy, and a similar episode in this site. He had a recent ingestion of raw eggs. He denied contact history with birds, insects or reptiles. The physical examination showed protrusion of the right cheek, of size 7 × 6 cm 2 , with central hyperemia and local heat. The oral cavity showed neither dilated papilla (soft tissue protuberance at the exit of the Stensen's duct) nor purulent substance from it. The facial nerve function was intact bilaterally.

The patient wanted a second opinion after taking oral antibiotics from an outside hospital. Fine-needle aspiration yielded 3 mL of purulent material. Laboratory tests demonstrated a white blood cell count of 11650/mm 3 (64% neutrophils, reference range 4 × 10 3 /mm 3 to 8.5 × 10 3 /mm 3 ) and C-reactive protein of 4.6 mg/L (normal reference less than 1 mg/L). Contrast-enhanced computed tomography [Figure 1] demonstrated an irregular ring-enhancing loculated lesion with a homogenous low-density substance inside, without evidence of sialolithiasis. Diagnosis was compatible with parotid abscess with reactive neck lymphadenopathy. The radiological imaging differential showed a necrotic tumor.
Figure 1: Head and neck computed tomography (CT) with contrast, axial view (a), coronal view (b), disclosed an irregular ring-enhancing loculated lesion in the right retromandibular region, measuring 5 4 4.5 cm3, closely jostling the deep lobe of the right parotid gland

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Emergent operative drainage of the abscess was performed and the intraoperative specimen grew Salmonella enterica serovar enteritidis (S. enteritidis), serotype B. Histopathology illustrated Warthin's tumor with infarction [Figure 2].
Figure 2: Histopathology shows a gross lesion containing an intact Warthin's tumor (▲) and localized necrotic debris (*) (hematoxylin and eosin stain, magnification 2.5); inset, shows the architecture of preserved dead tissue composed of eosinophilic, anucleate cells (hematoxylin and eosin staining, magnification 40)

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The relevant serology investigation for human immunodeficiency virus (HIV), diabetes mellitus, and pertinent autoimmune antibodies were all negative. Stool culture also grew S. enteritidis, group B. Consultation was then sought with physicians from Infectious Diseases. The diagnosis was solitary parotid gland extraintestinal salmonellosis within Warthin's tumor, secondary to uncomplicated bacteremia accompanying enterocolitis. Ceftriaxone 2 g every eight hours was previously administered and was replaced with ciprofloxacin 400 mg twice daily for a total of 14 days. Second-stage debridement and wound closure was performed seven days later, with complete remission of symptoms. The postoperative course was smooth and the wound healed well without facial nerve injury, fistula formation or recurrent abscess formation.

  Discussion Top

Bacteria of the genus Salmonella are facultative anaerobic gram-negative bacilli, which can be divided into two broad categories according to the clinical syndromes in human subjects. One category consists of typhoid serotypes (Salmonella typhi and Salmonella paratyphi), which cause classic typhoid fever, and the other are made up of non-typhoid serotypes (non-typhoidal Salmonella or NTS) that can colonize the gastrointestinal tracts of a broad range of animals, and more than 200 non-typhoid serotypes are pathogenic to humans. The epidemiology of NTS has evolved over time. In the past 10 years, S. Enteritidis (65% of isolates), S. Typhimurium (12%), and S. Newport (4%) [2] are the most common serotypes worldwide.

Non-typhoidal Salmonella cause four clinical syndromes in humans including diarrhea disease, invasive bacteremic illness, focal suppurative infection, and asymptomatic carriage in the stool. [3] An individual may show several of these. The most common initial symptoms are self-limited nausea and non-bloody diarrhea, without associated intestinal perforation. In our patient, it is very likely that the infection was acquired seven days earlier after ingestion of raw eggs, accounting for gastrointestinal symptoms.

Although less than 5% of the infected patients developed disseminated bacteremia or localized suppurative foci, it was significantly more likely in a population of immunocompromised adults, including underlying severe disease, chronic granulomatous disease, defects or blockade of specific cytokines, and HIV. These patients have dramatically a more severe and invasive presentation, markedly increased mortality, and may suffer recurrence. [4],[5] Common extraintestinal sites of infections include urinary tract, the endovascular structure, joints, long bone, and brain. [5],[6] Parotid abscess has been inadequately described in the past decades. However, the presence of a rapidly progressing infra-auricular firm mass, combined with the patient's ethnicity and contact history, should raise suspicion of a parotid NTS. The differential includes necrotic lymphadenopathy, infected salivary gland tumor or congenital cyst. Fluoroquinolones are a reasonable empiric antibiotic choice, while chloramphenicol, amoxicillin, and trimethoprim/sulfamethoxazole are reasonable alternatives. A 14-day course of therapy is likely adequate for otherwise healthy individuals, with uncomplicated bacteremia accompanying enterocolitis. [7]

A search of the English literature published since 1950 revealed only eight cases of parotid salmonellosis [Table 1]. All the eight patients were male. The age rage was 15 to 79 years, with a mean of 55.9 years. All the cases had underlying diseases, except for one subject. [14] Three had HIV and one had an inherent parotid tumor.
Table 1: Published literatures regarding parotid salmonellosis

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Among the patients having HIV, there were two cases [8],[9],[11] of parotid abscess, complicated with HIV-associated lymphoepithelial cysts. The pathogenesis was attributed to the diffuse infiltrative CD8 lymphocytosis syndrome and salivary cystic degeneration. Thus, it was assumed that the most likely etiology was sialectasis, secondary to the prolonged history of a parotid tumor. In combination with high virulence and inoculums from the blood stream infection secondary to enterocolitis, Salmonella spp. elicited development of a devastating soft tissue. Subsequent exudates into the ductal parenchyma promoted further destruction and subsequent abscess formation.

Parotid salmonellosis is not necessarily rare, but easily neglected. The case is informative from a microbiological point of view, with regard to the parotid abscess. Thus clinicians, especially in the endemic regions, should consider salmonellosis as a potential contributing etiology for parotid abscess, which necessitates surgical intervention for both therapeutic drainage and diagnostic purpose. [8],[9],[10],[11],[12],[13],[14],[15]

  References Top

1.Tan VE, Goh BS. Parotid abscess: A five-year review-clinical presentation, diagnosis and management. J Laryngol Otol 2007;121:872-9.  Back to cited text no. 1
2.Centers for Disease Control and Prevention (CDC). Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food - 10 states, 2009. MMWR Morb Mortal Wkly Rep 2010;59:418-22.  Back to cited text no. 2
3.Sánchez-Vargas FM, Abu-El-Haija MA, Gómez-Duarte OG. Salmonella infections: An update on epidemiology, management, and prevention. Travel Med Infect Dis 2011;9:263-77.  Back to cited text no. 3
4.Gordon MA. Salmonella infections in immunocompromised adults. J Infect 2008;56:413-22.  Back to cited text no. 4
5.Matheson N, Kingsley RA, Sturgess K, Aliyu SH, Wain J, Dougan G, et al. Ten years experience of Salmonella infections in Cambridge, UK. J Infect 2010;60:21-5.  Back to cited text no. 5
6.Hsu RB, Lin FY. Risk factors for bacteraemia and endovascular infection due to non-typhoid salmonella: A reappraisal. QJM 2005;98:821-7.  Back to cited text no. 6
7.Su LH, Chiu CH, Chu C, Ou JT. Antimicrobial resistance in nontyphoid Salmonella serotypes: A global challenge. Clin Infect Dis 2004;39:546-51.  Back to cited text no. 7
8.Rajamani KK, John G, John L. Salmonella parotid abscess. J Assoc Physicians India 1984;32:540.  Back to cited text no. 8
9.Grossenbacher R, Steiner D. Salmonella parotitis with abscess formation. Otolaryngol Head Neck Surg 1992;106:98-100.  Back to cited text no. 9
10.Georgilis K, Hadjiloukas L, Petrocheilou V, Mavrikakis M. Parotitis Due to Salmonella enteritidis. Clin Infect Dis 1994;19:798-9.  Back to cited text no. 10
11.Knee TS, Ohl CA. Salmonella parotitis with abscess formation in a patient with human immunodeficiency virus infection. Clin Infect Dis 1997;24:1009-10.  Back to cited text no. 11
12.Kosnik SD, Emmons WW, Pitman KT. Parotid abscess caused by Salmonella enteriditis in a patient with parotid masses. Am J Otolaryngol 2002;23:119-21.  Back to cited text no. 12
13.Reyes CV, Jensen JD. Parotid abscess due to salmonella enteritidis: A case report. Acta Cytol 2006;50:677-9.  Back to cited text no. 13
14.Moraitou E, Karydis I, Nikita D, Falagas ME. Case report: Parotid abscess due to Salmonella enterica serovar Enteritidis in an immunocompetent adult. Int J Med Microbiol 2007;297:123-6.  Back to cited text no. 14
15.Shen CH, Lin YS, Chang FY. Gas-forming parotid abscess in a diabetic patient: An unusual complication of Salmonella enteritidis bacteremia. Am J Med Sci 2008;336:504-7.  Back to cited text no. 15


  [Figure 1], [Figure 2]

  [Table 1]


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