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ORIGINAL ARTICLE
Year : 2014  |  Volume : 34  |  Issue : 6  |  Page : 241-246

Comparison of susceptibility of Enterobacteriaceae causing community-onset urinary tract infection to isepamicin and amikacin by the disc diffusion method


1 Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei; Penghu Branch, Tri-Service General Hospital, National Defense Medical Center, Penghu; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
2 Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
3 Songshan Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
4 Institute of Clinical Medicine, School of Medicine, National Yang-Ming University; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan

Correspondence Address:
Dr. Shu-Chen Kuo
Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 112
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1011-4564.147249

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Background: Enterobacteriaceae, common pathogens responsible for urinary tract infections are known to be susceptible to aminoglycosides. The emergence of resistant pathogens complicates antimicrobial regimen and becomes a challenge for clinicians. The aim of this study was to evaluate the susceptibility of clinically isolated Enterobacteriaceae to isepamicin and amikacin using disc diffusion method. Materials and Methods: A total of 234 Enterobacteriaceae isolates was collected and examined. Antimicrobial susceptibilities to gentamicin, amikacin, and isepamicin were assessed using disc diffusion method. The production of extended-spectrum β-lactamase (ESBL) or AmpC β-lactamase was also tested. The susceptibilities of the pathogens to isepamicin and amikacin were evaluated. Results: Two hundred and thirty-four Enterobacteriaceae isolates were found to be more susceptible to amikacin and isepamicin than to gentamicin. Of the isolates, 39 (16.7%) produced ESBL and 41 (17.5%) harbored AmpC β-lactamase. The results revealed that amikacin and isepamicin exerted excellent antibacterial activity (94% vs. 93.6%) against all tested isolates. Isepamicin was effective against 89.7% ESBL-producing isolates and 92.7% of AmpC-producing isolates. The susceptibility to amikacin and isepamicin established by the disc diffusion method was mostly consistent with the overall agreement estimated 99.6%. Conclusions: Isepamicin showed excellent activities against infections caused by Enterobacteriaceae, including strains harboring ESBL or AmpC beta-lactamase. The susceptibility of tested isolated to isepamicin measured by disc diffusion method is comparable to that of amikacin.


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