|Year : 2015 | Volume
| Issue : 5 | Page : 221-223
Tuberculous lymphadenitis and adrenalitis with concomitant Addison's disease: A need to diagnose and treat early
Ya-Li Chang, Shi-Wen Kuo, Leay-Kiaw Er
Department of Endocrinology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, R.O.C.
|Date of Submission||24-Apr-2015|
|Date of Decision||14-Jun-2015|
|Date of Acceptance||28-Jul-2015|
|Date of Web Publication||22-Oct-2015|
Department of Endocrinology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289, Jianguo Road, Xindian District, New Taipei City 231, Taiwan
Source of Support: None, Conflict of Interest: None
Extrapulmonary tuberculosis often proceeds with an indolent course until a substantially infected organ is destroyed. This fact creates a great diagnostic challenge for clinicians. We report a rare case of tuberculous lymphadenitis and bilateral tuberculous adrenalitis with concomitant Addison's disease successfully treated with antitubercular drugs and steroid replacement.
Keywords: Addison′s disease, extrapulmonary tuberculosis, primary adrenal insufficiency, tuberculous lymphadenitis, tuberculous adrenalitis
|How to cite this article:|
Chang YL, Kuo SW, Er LK. Tuberculous lymphadenitis and adrenalitis with concomitant Addison's disease: A need to diagnose and treat early. J Med Sci 2015;35:221-3
|How to cite this URL:|
Chang YL, Kuo SW, Er LK. Tuberculous lymphadenitis and adrenalitis with concomitant Addison's disease: A need to diagnose and treat early. J Med Sci [serial online] 2015 [cited 2020 Jun 4];35:221-3. Available from: http://www.jmedscindmc.com/text.asp?2015/35/5/221/167777
| Introduction|| |
Since the 1950s, as therapies for tuberculosis (TB) have emerged, autoimmune adrenalitis has exceeded TB as the leading cause of adrenal insufficiency in Western countries. Nevertheless, TB remains an important cause in developing countries. Primary adrenal insufficiency secondary to adrenal TB is rare in current practice, and the clinical manifestations are mostly nonspecific, so it is often overlooked. Herein, we report a case of tuberculous lymphadenitis and bilateral tuberculous adrenalitis with a typical presentation of primary adrenal insufficiency successfully treated with antitubercular drugs and steroid replacement.
| Case Report|| |
A 71-year-old female presented to our Emergency Department with nausea, vomiting and dizziness that had progressively worsened over the last 2 months. Two months ago, she sought advice from general practitioners several times. However, her symptoms did not lead to a diagnosis.
The patient had a history of left nephrectomy for renal stones, and excision of a right cervical lymph node with a pathology report of chronic granulomatous inflammation without further management 2 years ago. She denied any history of TB infection or malignancy. On admission, her vital signs were stable. She denied having a cough, abdominal pain, weight loss, fever, or night sweating. Laboratory studies showed normal white blood cell counts. Biochemistry tests including alanine transaminase, lipase, and plasma glucose were normal. The serum sodium was extremely low, 109 mmol/L, and potassium was 4.7 mmol/L. Serum osmolality was 236 mOsm/kg, urine osmolality was 402 mOsm/kg, and the urinary sodium concentration was 109 mmol/L. Physical examination revealed hyperpigmentation in the patient's palmar creases, knuckles, face (freckles), lips and gums [Figure 1]a, and longitudinal lines on the nails [Figure 1]b. We found three enlarged lymph nodes in the right neck. Further laboratory workup for hyponatremia revealed high morning plasma adrenocorticotropic hormone, at 716 pg/ml (reference range 5-77 pg/ml), and low morning serum cortisol, at 6.18μg/dl (reference range 5-25 μg/dl). Results of the endocrinological test and skin hyperpigmentation strongly suggested chronic primary adrenal insufficiency. Mineralocorticoid deficiency was also proved by low-normal plasma aldosterone, at 7.86 ng/dl (reference range 7-35 ng/dl) and elevated plasma renin activity, at 8.93 ng/ml/h (reference range 1.31-3.95 ng/ml/h).
|Figure 1: (a) Hyperpigmentation in the patient's face (freckles), lips and gums, and (b) Longitudinal hyperpigmentation on the nails|
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Right cervical lymph node excisional biopsy was then performed and pathology revealed caseous granuloma [Figure 2]a, yet no acid-fast bacilli in the special stain. No acid-fast bacilli were found in the special stain or culture of sputum. Chest X-ray was unremarkable. However, the abdominal contrasted computed tomography (CT) scan revealed a heterogeneous right adrenal tumor measuring 3.66 cm × 2.26 cm, soft tissue with dense calcification measuring 1.59 cm × 0.76 cm in the left suprarenal space and enlarged lymph nodes in the left iliac and paraaortic region [Figure 2]b and c. Extrapulmonary TB, involving bilateral adrenal glands, right cervical, and multiple intra-abdominal lymph nodes was highly suspected. The patient refused adrenal CT-guided needle biopsy.
|Figure 2: (a) Right neck lymph node biopsy specimen showing caseous granuloma with Langhans giant cells (arrow), (b) (before treatment) Soft tissue measuring 1.59 cm × 0.76 cm, with dense calcifi cation in the left suprarenal space, (c) (before treatment) Abdominal computed tomography scan showing a heterogeneous tumor measuring 3.66 cm × 2.26 cm, with preserved contour and peripheral enhancement in the right adrenal gland, (d) Much regression of the right adrenal mass after 18 months of anti-tuberculosis treatment|
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The patient's general symptoms dramatically improved after initiation of steroid treatment (glucocorticoid and fludrocortisone) which was adjusted based on the clinical symptoms and electrolyte concentration. We started empiric anti-TB treatment, including rifampicin, isoniazid, pyrazinamide, and ethambutol that was maintained for 18 months. Sequential abdominal CT scans during and after complete anti-TB treatment revealed a significant reduction of the bilateral adrenal gland tumor within the 18 months [Figure 2]d. The enlarged cervical, paraaortic, and iliac lymph nodes disappeared after 6 months of anti-TB treatment. The hyperpigmentation also gradually faded 6 months following steroid replacement; the disappearance of longitudinal hyperpigmentation on the nails was especially impressive. At present, 6 years after diagnosis, the patient feels well and maintains on steroid replacement.
| Discussion|| |
In a few large studies, the incidence of extrapulmonary TB has approached 5% of active TB cases; however, it exceeded that in an autopsy series.  In a large retrospective analysis of autopsies, the adrenal gland was the fifth most common site of extrapulmonary TB. Primary adrenal insufficiency occurred in only 15% of patients with adrenal TB.  The clinical features of adrenal insufficiency are not noted until over 90% of the adrenal glands have been destroyed.  The clinical symptoms of primary adrenal insufficiency are mostly nonspecific. Therefore, it is often overlooked and eventually leads to a delayed diagnosis, even when unique hyperpigmentation is present.
Percutaneous adrenal biopsy has been proven to be of great value, with 90% accuracy in determining the final diagnosis of adrenal masses in patients with a history of malignancy; however, in other pathologic conditions, such as adenomas, infectious disease, primary malignant tumors, or adrenal hemorrhage, its application is much more limited.  Fine-needle aspiration is also not helpful in diagnosing adrenal TB. In nononcologic patients, a more conservative diagnostic approach is suggested.  As such we did not go ahead with percutaneous adrenal biopsy in this patient and performed right neck lymph node biopsy instead, to study the possible link with adrenal tumor. The pathology of cervical lymph node biopsy revealed a surprising result: Caseous granuloma.
The radiological pattern may be crucial to supporting the diagnosis of adrenal TB infection without a histological process. Contrast-enhanced CT could provide evidence of a series of specific characteristics, including bilateral involvement, contour preservation, peripheral enhancement, and calcification to discriminate adrenal TB from primary tumors.  Another study suggested that the difference in the CT attenuation value of the tuberculous lesion was less in the central area than in the peripheral area between the unenhanced and contrast-enhanced scan.  We were able to find all the above-mentioned imaging characteristics in the CT images of our patient. These findings strongly supported the presumptive diagnosis of adrenal TB. The diagnosis was solidified by the remarkable regression of the right adrenal tumor and the disappearance of paraaortic and iliac lymph nodes in serial abdominal CT scans after complete anti-TB treatment.
The proportion of residual viable adrenal tissue at the time of diagnosis and the adequacy of anti-TB treatment determine the resumption of adrenal function. Despite the fact that the adrenal gland cortex has considerable capacity for regeneration, and effective anti-TB therapy may lead to some recovery of hormonal, adrenal function, patients usually have to remain on hormone replacement therapy.  In addition, a large population-based study  found increased mortality in patients with primary adrenal insufficiency. Thus, we emphasize the importance of a timely diagnosis of primary adrenal insufficiency to prevent further complications.
| Conclusion|| |
CT images of adrenal tumors associated with the pathology of accessible superficial lesions may provide powerful hints to the diagnosis of adrenal TB. Prompt anti-TB treatment and hormone replacement should be given to minimizing the patient's morbidity. It is imperative that health professionals should bear in mind the typical clinical presentation of primary adrenal insufficiency to make an early diagnosis and improve the patient's quality of life.
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[Figure 1], [Figure 2]