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CASE REPORT
Year : 2015  |  Volume : 35  |  Issue : 5  |  Page : 224-225

Concurrent hypokalemic periodic paralysis and bipolar disorder


1 Department of Psychiatry, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan
2 Dr. Shiah's Psychiatric Clinic, Taipei, Taiwan

Correspondence Address:
I-Shin Shiah
Dr. Shiah's Psychiatric Clinic, Floor 4, No 143, Cheng-Gong Road, Section 3, Nei-Hu District, Taipei 114
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1011-4564.167779

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Primary periodic paralysis is a rare autosomal dominant disorder of ion-channel dysfunction, manifested by episodic flaccid paresis secondary to abnormal sarcolemma excitability. Membrane destabilization involving Na, K-ATPase has been hypothesized to be a biological etiology of the bipolar disorder (BD) and the mechanisms underlying lithium therapy have been linked to it. To date, there has been only one reported case of BD comorbid with periodic paralysis. Herein, we reported another case of concurrent bipolar mania and hypokalemic periodic paralysis (HPP), one special form of periodic paralysis. Consistent with the previous case, our patient responded well to lithium treatment for both bipolar mania and HPP. This might provide some support to the hypothesis that the therapeutic effects of lithium in both BD and HPP could be due to the correction of the underlying common pathophysiology.


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