|Year : 2016 | Volume
| Issue : 1 | Page : 28-30
Altered consciousness following head injury in advanced renal failure: Find the culprit
Kun-Lin Wu1, Sung-Sen Yang2, Chih-Chien Sung2, Shih-Hua Lin2
1 Department of Medicine, Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei; Department of Medicine, Armed Forces Taoyuan General Hospital, Taoyuan, Taiwan, Republic of China
2 Department of Medicine, Armed Forces Taoyuan General Hospital, Taoyuan, Taiwan, Republic of China
|Date of Submission||14-Aug-2015|
|Date of Decision||24-Sep-2015|
|Date of Acceptance||25-Oct-2015|
|Date of Web Publication||23-Feb-2016|
Division of Nephrology, Department of Medicine, Tri-Service General Hospital, No. 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan
Republic of China
Source of Support: None, Conflict of Interest: None
Conscious change following head injury needs a scrutiny of the "nontraumatic" cause to avoid inappropriate management and catastrophic complication. We described an 81-year-old diabetic woman with advanced chronic kidney disease (CKD) (estimated glomerular filtration rate: 6 ml/min/1.73 m 2 ) re-presented to Emergency Department with altered mentality and generalized muscular hypotonia 2 days after falling with a head injury. Her initial mentality was alert, and computed tomography of the brain was negative for organic lesions; she has been given oral baclofen 10 mg daily to control her associated spastic back pain. The repeated laboratory and imaging studies were still unrevealing. Her serum baclofen concentration was markedly elevated (1437 ng/ml). With emergent hemodialysis for two sessions, complete elimination of serum baclofen concentration was accompanied by full recovery of her consciousness. Nontraumatic causes, especially drug-induced neurotoxicity, must be kept in mind in traumatic patients with CKD and unexplained neurological feature.
Keywords: Baclofen, encephalopathy, hemodialysis
|How to cite this article:|
Wu KL, Yang SS, Sung CC, Lin SH. Altered consciousness following head injury in advanced renal failure: Find the culprit. J Med Sci 2016;36:28-30
|How to cite this URL:|
Wu KL, Yang SS, Sung CC, Lin SH. Altered consciousness following head injury in advanced renal failure: Find the culprit. J Med Sci [serial online] 2016 [cited 2020 Jan 25];36:28-30. Available from: http://www.jmedscindmc.com/text.asp?2016/36/1/28/177175
| Introduction|| |
Conscious change after traumatic head injury can result from either direct traumatic or indirect nontraumatic causes. The traumatic causes include epidural hemorrhage, chronic subdural hemorrhage, severe brain swelling, and hydrocephalus, which can be rapidly confirmed by imaging studies. On the other hand, nontraumatic causes including toxins, drugs, metabolic abnormalities, infection, seizure, and psychogenic diseases should be cautiously assessed to avoid missing treatable or curable causes. In this study, we described an 81-year-old diabetic woman with advanced chronic kidney disease (CKD) and preceding head injury manifested progressive, conscious change caused by baclofen-induced neurotoxicity resolved by emergent hemodialysis (HD).
| Case Report|| |
An 81-year-old woman presented to emergency department (ED) with comatose consciousness and generalized muscular hypotonia. She had a medical history of type 2 diabetes mellitus with advanced CKD (estimated glomerular filtration rate [GFR]: 6 ml/min/1.73 m 2 ) on regular medication including acarbose, amlodipine, valsartan, and furosemide. Two days ago, she was sent to ED with a headache and spastic back pain after falling in the bathroom. Her consciousness was alert, and the impression of a minor head injury with brain contusion was made by the unrevealing laboratory and imaging studies including computed tomography (CT) of the brain. She was given with medicine of acetaminophen 375 mg and baclofen 5 mg twice daily to treat her symptoms. Altered consciousness gradually developed and persisted for 12 h before arriving to ED again.
The vital signs were Glasgow Coma Scale E1M4V1, blood pressure 162/80 mmHg, heart rate 94/min, temperature 36.5°C, respiratory rate 18/min, and oxygen saturation 95-97% with 6 L/min of oxygen by nasal cannula. Further, pertinent neurological examinations demonstrated muscular hypotonia and generalized hyporeflexia. The laboratory tests showed serum sodium 135 mEq/L, potassium 5.2 mEq/L, chloride 103 mEq/L, serum urea nitrogen 73 mg/dL, creatinine 7 mg/dL, aspartate transaminase 23 U/L, alanine transaminase 24 U/L, glucose 118 mg/dL, albumin 3.9 g/dL, white blood cells 8,900/mm 3 , hemoglobin 9.8 g/dL, and platelets 143,000/mm 3 . The toxicological screens, electrocardiogram, and chest film were unremarkable. A repeated CT of the brain did not reveal any delayed organic lesion.
After the exclusion of traumatic causes, nontraumatic neurotoxicity caused by the accumulative baclofen was highly suspected due to the strong history of taking renally-eliminated baclofen, which may cause neurological symptoms in advanced CKD. A high serum baclofen concentration (1437 ng/ml) supported this diagnosis. With two sessions of emergent 4 h HD, the neurological symptom was completely reversed, and serum baclofen level was also undetectable [Figure 1]. Her hospital course was uneventful, but she was put on regular HD due to uremia.
|Figure 1: A serial serum baclofen concentration treated hemodialysis. C0: Initial concentration, C1: Concentration at the end of the first hemodialysis, C2: Concentration at the beginning of the second hemodialysis, C3: Concentration at the end of the second hemodialysis|
Click here to view
| Discussion|| |
This elderly and diabetic female with advanced CKD presented with unexplained coma 2 days following preceding head injury. The traumatic causes were excluded by brain imaging studies. She was established to have baclofen-induced encephalopathy based on the strong history of taking baclofen, elevated serum baclofen concentration, and resolution of neurological features with HD to eliminate baclofen accumulation. Drugs which were used and may potentially lead to neurotoxicity in traumatic patients with advanced CKD are shown in [Table 1].
Baclofen, g-aminobutyric acid derivative, is usually used to treat skeletal spasticity or refractory hiccups in a therapeutic serum range 80-400 ng/ml. It is mainly excreted in unchanged form by the kidneys (69-85%) with a half-life of 4.5-6.8 h. Of note, baclofen is prone to be uptake in the central nervous system once accumulated, leading to neurotoxicity or encephalopathy. This has been reported with the minimally accumulative baclofen 10 mg in CKD patients not yet on dialysis. ,, Our patient developed neurotoxicity with a serum level up to 1437 ng/mL just after the administration of baclofen 10 mg/days for 1 day, supporting that its accumulative effect can occur in a very short period in advanced CKD. Some cumulative mechanisms secondary to renal failure are responsible for baclofen-induced neurotoxicity. First, baclofen accumulation phenomenon can occur because its renal elimination decline.  Second, there is mounting evidence that renal impairment impacts the hepatic cytochrome P450 activity and acetylation, inducing the diminishing of hepatic drug metabolism on nonrenal clearance and bioavailability.  Third, P-glycoprotein inhibition due to renal failure in blood-brain barrier may induce drug accumulation in the brain.  Furthermore, aging reduces drug distribution and increases plasma concentration when most of the reported baclofen-induced neurotoxicity occurred in the elders. 
Given the small molecular weight (213 Da) and low protein binding (30%) of baclofen, high-flux HD can remove 37% active baclofen for 4 h-HD and effectively reduce the half-life to 2.06-3.7 h based on one-compartment model with the equation: C = C 0 e−Kt (C: Baclofen serum concentration, K: Elimination rate constant, t: Time). , In our patient, the half-life of serum baclofen with HD was 2.1 h but increased up to 10.2 h during the non-HD period.
CKD with high prevalence 8-16% is recognized as worldwide public health issue,  and these patients are at high risk for drug accumulation and toxicity. Drug-induced encephalopathy is often misinterpreted as other causes and should be kept in mind with CKD and unexplained neurological feature. Our case reiterates the importance of a scrutiny for the "nontraumatic" cause in any traumatic patient with advanced CKD and unexplained neurological symptoms to avoid inappropriate management and catastrophic complication. In [Table 1], we suggest drug dosing adjustments and avoid the use of baclofen in the patient with estimated GFR < 10 ml/min/1.73 m 2 .
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Chou CL, Chen CA, Lin SH, Huang HH. Baclofen-induced neurotoxicity in chronic renal failure patients with intractable hiccups. South Med J 2006;99:1308-9.
Wu VC, Lin SL, Lin SM, Fang CC. Treatment of baclofen overdose by haemodialysis: A pharmacokinetic study. Nephrol Dial Transplant 2005;20:441-3.
Brvar M, Vrtovec M, Kovac D, Kozelj G, Pezdir T, Bunc M. Haemodialysis clearance of baclofen. Eur J Clin Pharmacol 2007;63:1143-6.
Gibson TP, Matusik E, Nelson LD, Briggs WA. Artificial kidneys and clearance calculations. Clin Pharmacol Ther 1976;20:720-6.
Simard E, Naud J, Michaud J, Leblond FA, Bonnardeaux A, Guillemette C, et al.
Downregulation of hepatic acetylation of drugs in chronic renal failure. J Am Soc Nephrol 2008;19:1352-9.
Boord A, Benson B. Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease. Am J Health Syst Pharm 2007;64:2241-3.
Bek K, Koçak S, Ozkaya O, Yilmaz Y, Aydin OF, Tasdöven CS. Carbamazepine poisoning managed with haemodialysis and haemoperfusion in three adolescents. Nephrology (Carlton) 2007;12:33-5.
Fernandez MC, Walter FG, Kloster JC, Do SM, Brady LA, Villarin A, et al
. Hemodialysis and hemoperfusion for treatment of valproic acid and gabapentin poisoning. Vet Hum Toxicol 1996;38:438-43.
LaRoche SM, Helmers SL. The new antiepileptic drugs: scientific review. JAMA 2004;291:605-14.
Jamal JA, Joh J, Bastani B. Removal of morphine with the new high-efficiency and high-flux membranes during haemofiltration and haemodialfiltration. Nephrol Dial Transplant 1998;13:1535-7.
Gibson TP. Pharmacokinetics, efficacy, and safety of analgesia with a focus on tramadol HCl. Am J Med 1996;101:47S-53S.
Hsu CH, Lin TC, Lu CC, Lin SH, Ho ST. Clearance of meperidine and its metabolite normeperidine in hemodialysis patients with chronic noncancer pain. J Pain Symptom Manage 2014;47:801-5.
Garza MB, Osterhoudt KC, Rutstein R. Central anticholinergic syndrome from orphenadrine in a 3 year old. Pediatr Emerg Care 2000;16:97-8.
Roberge RJ, Atchley B, Ryan K, Krenzelok EP. Two chlorzoxazone (Parafon forte) overdoses and coma in one patient: reversal with flumazenil. Am J Emerg Med 1998;16:393-5.
Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al
. Chronic kidney disease: Global dimension and perspectives. Lancet 2013;382:260-72.