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ORIGINAL ARTICLE
Year : 2016  |  Volume : 36  |  Issue : 5  |  Page : 180-187

The association of hematological parameters and metabolic syndrome in an older population: A cross-sectional and longitudinal study


1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, Republic of China
2 Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taiwan, Republic of China
3 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan, Republic of China
4 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taiwan, Republic of China
5 Department of Life Science, Institute of Applied Science and Engineering, College of Science and Engineering, Fu-Jen Catholic University, Taiwan, Republic of China
6 Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taiwan, Republic of China
7 Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center; Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, Republic of China

Correspondence Address:
Chang-Hsun Hsieh
Department of Internal Medicine, National Defense Medical Center, Division of Endocrinology and Metabolism, Tri-Service General Hospital, #325, Section 2, Chenggong Road, Neihu District, Taipei, Taiwan
Republic of China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1011-4564.192825

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Objective: Hematological parameters play a significant role in metabolic syndrome (MetS) and its development in the elderly, but the association and different ability of each parameter to predict MetS have not been investigated in the very old populations. Subjects and Methods: This cross-sectional and longitudinal study included 18,907 participants aged over 65 years and followed up until MetS development with a mean duration of 4 years from the entry date. MetS was diagnosed according to the latest harmonized criteria with modification for waist circumference. Correlations between hematological parameters and MetS were analyzed and operating characteristic curves were compared among each parameter. Stratification was conducted by gender and age as follows: young-old (65-74 years), old-old (75-84 years), and oldest-old (85-94 years). Results: White blood cell count (WBC) and hemoglobin (Hb) levels in both genders of young-old (65-74 years) and old-old (75-84 years) and platelet (PLT) in young-old (65-74 years) males were independent factors for risk of MetS. However, only WBC (P < 0.001) and Hb level (P < 0.001) in young-old (65-74 years) males and Hb level (P = 0.03) in old-old (75-84 years) females were independent factors of future MetS development. For predicting MetS, WBC and Hb levels were better markers than PLT in the old-old (75-84 years) and young-old (65-74 years) males group. In young-old (65-74 years) females, WBC was the most sensitive marker. Conclusions: Hematological parameters were associated with MetS, showing gender and age effects. These findings can be used for risk estimation of MetS development in the older population.


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