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CASE REPORT
Year : 2017  |  Volume : 37  |  Issue : 5  |  Page : 211-214

Demyelinating polyneuropathy, dermatomyositis, and interstitial pneumonitis associated with autoantibody against melanoma differentiation-associated gene 5


1 Department of Internal Medicine, Division of Rheumatology, Immunology and Allergy, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China
2 Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China

Correspondence Address:
Chun-Chi Lu
Department of Internal Medicine, Division of Rheumatology, Immunology and Allergy, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
Republic of China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmedsci.jmedsci_56_17

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Patients with serum anti-melanoma differentiation-associated gene 5 autoantibodies (anti-MDA5) are related to amyopathic dermatomyositis, especially in Asians. Here, we present a 46-year-old woman who was diagnosed with anti-MDA5-mediated demyelinating polyneuropathy clinically mimicking dermatomyositis. She had rapid progression of interstitial pneumonitis complicated with Pneumocystis jirovecii and Aspergillus pneumonia with septic shock. It is rare that patients with anti-MDA5-positive dermatomyositis present as demyelinating polyneuropathy.


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