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ORIGINAL ARTICLE
Year : 2018  |  Volume : 38  |  Issue : 5  |  Page : 204-210

Application of stereotactic ablative radiotherapy in hepatocellular carcinoma patients with child–turcotte–pugh class B liver function


1 Department of Radiation Oncology, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
2 Department of Radiation Oncology, National Defense Medical Center, Tri-Service General Hospital; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
3 Department of Radiology, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
4 Department of Surgery, Division of Colon and Rectal Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
5 Department of Radiation Oncology, National Defense Medical Center, Tri-Service General Hospital; College of Medicine, Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan

Correspondence Address:
Dr. Chun-Shu Lin
Department of Radiation Oncology, National Defense Medical Center, Tri-Service General Hospital, No. 325, Sec 2, Cheng-Gong Road, Neihu, Taipei 11481
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmedsci.jmedsci_156_17

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Background: The aim of this study is to evaluate the outcomes and prognostic factors in patients with hepatocellular carcinoma (HCC) and Child–Turcotte–Pugh (CTP) class B liver function after stereotactic ablative radiotherapy (SABR). Materials and Methods: This retrospective study evaluated patients with HCC and impaired liver function who underwent SABR between December 2007 and August 2016. All patients had CTP class B liver function before treatment. Local control (LC) rate, overall survival (OS) rate, prognostic factors, and radiation-related toxicity were evaluated. Results: This study included 34 patients. The majority had a CTP score of B7 (52.9%) and advanced HCC (91.2%). The median survival time was 4.8 months, and the 1-year OS rate was 21.4%. Only the tumor number (multiple vs. single) was identified as an independent predictor of survival. The 1-year LC rate was 95.8%. Eight patients (23.5%) developed the radiation-induced liver disease, and 15 (44.1%) had a CTP score decline of ≥2 within 3 months. Other toxicities were generally tolerable. Conclusion: SABR may be considered as an alternative option for patients with HCC and CTP class B liver function, particularly for those with a single lesion.


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