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LETTER TO EDITOR
Year : 2019  |  Volume : 39  |  Issue : 5  |  Page : 254

Observation on silver nanoparticle interference on dichlorophenol indophenol precipitation test


1 TWS Medical Center, Bangkok, Thailand
2 Department of Biological Science, Joseph Ayobabalola University, Ilara-Mokin, Nigeria

Date of Submission12-Nov-2018
Date of Decision14-Mar-2019
Date of Acceptance25-Mar-2019
Date of Web Publication06-May-2019

Correspondence Address:
Dr. Pathum Sookaromdee
TWS Medical Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmedsci.jmedsci_180_18

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How to cite this article:
Sookaromdee P, Wiwanitkit V. Observation on silver nanoparticle interference on dichlorophenol indophenol precipitation test. J Med Sci 2019;39:254

How to cite this URL:
Sookaromdee P, Wiwanitkit V. Observation on silver nanoparticle interference on dichlorophenol indophenol precipitation test. J Med Sci [serial online] 2019 [cited 2019 Dec 15];39:254. Available from: http://www.jmedscindmc.com/text.asp?2019/39/5/254/257756

Dear Editor,

Nowadays, nanoparticle is widely used in daily life. The effect of nanoparticle interference on hematological examination is interesting, and the data on the interference are limitedly mentioned in the literature. The authors performed an experimental study to assess the effect of silver nanoparticle interference on dichlorophenol indophenol precipitation (DCIP) test, which is a standard reference test for the hemoglobin E disorder screening.[1] Thirty blood samples are used. Each sample is divided into two equal parts. Then, the first one was left naive and 1 μl of the silver nanoparticle solution was added into the left one. This evaluation protocol for the effect of the nanoparticle is the same as that published in the previous reports on the evaluation of the effect of nanoparticle on viral load test.[2] DCIP test was done in each sample in the same clinical laboratory at the same time under the same standard quality control process. Considering the results, all samples in the naive control group have negative DCIP test results, whereas three samples in the nanoparticle-added solution have positive results and classified as false-positive results (inaccuracy rate equal to 10%) [Table 1]. This report is the first world report on the effect of nanoparticle interference with DCIP test.
Table 1: The original comparison data of negative control and nanoparticle-added groups

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This study is a standard evaluation on interference effect in laboratory medicine. The main aim is the assessment of interference with DCIP test. It is not a study of a new diagnostic test that should show a new diagnostic test, which is cost-effective and reduce time-consuming. The high false-positive rate (10%) can show that there is an interference of nanoparticle on DCIP test. The main advantage of the present study is a new knowledge of nanoparticle interference with DCIP test. It is necessary to check for the contamination of nanoparticle in DCIP laboratory. The silver nanoparticle interference effect should be investigated in other hematological laboratory examinations.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Tongsong T, Sirichotiyakul S, Chaisen R, Wanapirak C. Sensitivity and specificity of dichlorophenol – Indophenol precipitation test to screen for the hemoglobin E trait in pregnant women. Int J Gynaecol Obstet 2006;95:149-50.  Back to cited text no. 1
    
2.
Yasri S, Wiwanitkit V. Effect of gold nanoparticle on viral load of hepatitis C virus. J Coast Life Med 2014;2:500.  Back to cited text no. 2
    



 
 
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