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Knee joint injection resveratrol amelioration inflammation in collagen antibody induced arthritis

1 Hualien Armed Forces General Hospital, Hua Lien, Taiwan
2 National Defense Medical Center; National Defense Medical Center, Graduate Institute of Life Sciences, Taipei, Taiwan
3 National Defense Medical Center, Graduate Institute of Medical Sciences; Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan
4 National Defense Medical Center, Graduate Institute of Medical Sciences, Taipei, Taiwan
5 National Defense Medical Center, Graduate Institute of Medical Sciences, Taipei; National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu, Taiwan

Correspondence Address:
Wei-Tso Chia,
No. 25, Lane 442, Sec. 1, Jingguo Rd., Hsinchu 300
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmedsci.jmedsci_8_19

Background: Resveratrol has been considered to possess anti-inflammatory properties. Here, we propose that intra-articular resveratrol injection might ameliorate acute inflammation in a single knee joint in mice with collagen antibody-induced arthritis (CAIA). Methods: The clinical expression of CAIA was analyzed by two investigators. Resveratrol (30 mg/kg in 30 μL dimethyl sulfoxide [DMSO]) was injected into the knee joint of BALB/c mice from days 0 to 9. Footpad thickness was photographed and calculated. On day 10, the joints were examined histopathologically. Serum cytokine levels were measured by enzyme-linked immunosorbent assay. mRNA levels in paws were measured by real-time polymerase chain reaction (PCR). Results: In CAIA, acute inflammation was induced on day 7 and continued until day 10. In the resveratrol-treated mice, the severity of inflammation was obviously reduced. Expression levels of interleukin-1β, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase were decreased in the treated mice; however, tumor necrosis factor-α (TNF-α) levels did not change significantly after treatment. Conclusion: The anti-inflammatory mechanism of resveratrol is associated with NF-κB inhibition. Further investigations of the clinical applications of resveratrol are required.


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