Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 34  |  Issue : 2  |  Page : 56--61

Antroquinonol, an active pure compound from Antrodia camphorate mycelium, modulates the development of atherosclerosis in a mouse carotid artery ligation model


Tsai-Jung Lin1, Yun-Yi Lee2, Bieng-Hsian Tzeng3, Shih-Ping Yang3, Cheng-Wen Ho2, Dueng-Yuan Hueng4, Jia-Ming Chang5, Kun-Lun Huang2, Fu-Gong Lin6, Ann Chen7, Yeukuang Hwu8, Shuk-Man Ka2 
1 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
2 Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
3 Department of Medicine, Division of Cardiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
4 Department of Neurological Surgery, Tri-Service General Hospital; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
5 Department of Animal Pharmacology, Development Center for Biotechnology, Taipei, Taiwan, Republic of China
6 School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
7 Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
8 Institute of Physics, Academia Sinica, Nan-Kang, Taipei, Taiwan, Republic of China

Correspondence Address:
Prof. Shuk-Man Ka
Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, No. 161, Section 6, Min-Quan E. Road, Taipei, Taiwan
Republic of China

Background: Antroquinonol (Antroq) is an active component of Antrodia camphorate. The present study was to validate the preventive effects of Antroq in an atherosclerosis model. Materials and Methods: We examined Antroq inhibitory effect on rat aortic smooth muscle cell proliferation and migration and evaluated its effect on neointima formation and inflammation in mouse carotid artery ligation (CAL). Results: Our data show that Antroq [1] inhibited the proliferation (Antroq [3.0 μg/ml] + PDGF 41.7 ± 7.3%, vehicle + PDGF 134.5 ± 7.3%) (p<0.005) and migration (6h: Antroq [3.0 μg/ml] + PDGF 0.9 ± 0.3%, vehicle + PDGF 25.0 ± 3.4%; 12h: Antroq [3.0 μg/ml] + PDGF 4.0 ± 1.6%, vehicle + PDGF 40.5 ± 2.2%; 24h: Antroq [3.0 μg/ml] + PDGF 14.2 ± 3.0%, vehicle + PDGF 59.8 ± 3.3%) (each, p<0.005) of the cultured smooth muscle cells, [2] prevented neointima formation and reduced N/M ratios in CAL mice (900 μm: Antroq + CAL 0.8 ± 0.3, CAL 3.5 ± 1.1; 800 μm: Antroq + CAL 0.6 ± 0.2, CAL 3.5 ± 0.7; 700 μm: Antroq + CAL 0.7 ± 0.2, CAL 3.8 ± 0.4; 600 μm: Antroq + CAL 0.9 ± 0.2, CAL 3.8 ± 0.9; 500 μm: Antroq + CAL 1.3 ± 0.4, CAL 3.9 ± 0.8; 400 μm: Antroq + CAL 1.5 ± 0.5, CAL 4.0 ± 1.0; 300 μm: Antroq + CAL 1.8 ± 0.6, CAL 3.5 ± 0.6; 200 μm: Antroq + CAL 2.3 ± 0.6, CAL 4.6 ± 1.1) (each, p<0.01), [3] and prevented inflammatory processes and matrix accumulation/fibrosis in the CAL mice. Conclusions: Our data may be useful in developing new and practical strategy for the prevention of atherosclerosis based on the pathogenesis of the disorder.


How to cite this article:
Lin TJ, Lee YY, Tzeng BH, Yang SP, Ho CW, Hueng DY, Chang JM, Huang KL, Lin FG, Chen A, Hwu Y, Ka SM. Antroquinonol, an active pure compound from Antrodia camphorate mycelium, modulates the development of atherosclerosis in a mouse carotid artery ligation model.J Med Sci 2014;34:56-61


How to cite this URL:
Lin TJ, Lee YY, Tzeng BH, Yang SP, Ho CW, Hueng DY, Chang JM, Huang KL, Lin FG, Chen A, Hwu Y, Ka SM. Antroquinonol, an active pure compound from Antrodia camphorate mycelium, modulates the development of atherosclerosis in a mouse carotid artery ligation model. J Med Sci [serial online] 2014 [cited 2019 Sep 15 ];34:56-61
Available from: http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2014;volume=34;issue=2;spage=56;epage=61;aulast=Lin;type=0