Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 38  |  Issue : 3  |  Page : 113--116

Serum procalcitonin levels of patients with candidemia hospitalized in Intensive Care Units


Mohammad Reza Yazdani, Farzin Khorvash, Atousa Hakamifard 
 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Atousa Hakamifard
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan
Iran

Objective: Fungal infections are a main reason for mortality of critically ill patients in Intensive Care Units (ICUs). Recently, fungal infections have been on rise. Lack of a specific marker for fungal infections has led to some problems in diagnosing these infections. Scant data exist on serum procalcitonin (PCT) levels in high-risk patients with invasive fungal infections, such as ICU patients. Materials and Methods: In this prospective study conducted in 2014–2015 in Al-Zahra Hospital, Isfahan, Iran, 64 people were investigated. The PCT levels of the patients were measured at 0, 24, 48, and 72 h as well as 7 and 14 days of the ICU stay. Moreover, a blood sample was taken from each person every 3 days and examined for positive BACTEC Candida fungal culture. Results: Nine (15%) patients had candidemia. The mean serum PCT level was not significantly different between the patients with and without candidemia at admission and 24, 48, and 72 h of the ICU stay (P > 0.05), but was significantly different on 7 and 14 days of the ICU stay (P < 0.001). Conclusion: This study demonstrated that the serum PCT levels increased significantly in the patients with candidemia hospitalized in ICUs. Therefore, serum PCT, as a marker, can be relied on, in addition to other symptoms and factors, for taking a decision about the initiation of treatment with antifungal drugs. Besides that, further studies with larger sample size are recommended to examine the predictive value of PCT for invasive fungal infections.


How to cite this article:
Yazdani MR, Khorvash F, Hakamifard A. Serum procalcitonin levels of patients with candidemia hospitalized in Intensive Care Units.J Med Sci 2018;38:113-116


How to cite this URL:
Yazdani MR, Khorvash F, Hakamifard A. Serum procalcitonin levels of patients with candidemia hospitalized in Intensive Care Units. J Med Sci [serial online] 2018 [cited 2019 Nov 12 ];38:113-116
Available from: http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2018;volume=38;issue=3;spage=113;epage=116;aulast=Yazdani;type=0