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  Indian J Med Microbiol
 

Figure 1. Valproic acid (VPA) inhibits SAS cell growth in vitro. (a) Morphological changes in SAS cells treated with 0, 1, 2, 4 mM VPA for 24 h. The density of cultured cells reduced with VPA treatment. The survival of VPA-treated SAS cells was assessed at (b) 24 h (c) 48 h (d) 72 h with various concentrations. There were significant differences in the survival of SAS cells at the indicated VPA concentrations. After 72 h of treatment, the IC50 of VPA was approximately 2 mM for SAS cells. Survival proportions for SAS cells showed statistically significant differences in values when compared with the vehicle control groups (n = 3; *P < 0.05; **P < 0.01; ***P < 0.001)

Figure 1. Valproic acid (VPA) inhibits SAS cell growth <i>in vitro</i>. (a) Morphological changes in SAS cells treated with 0, 1, 2, 4 mM VPA for 24 h. The density of cultured cells reduced with VPA treatment. The survival of VPA-treated SAS cells was assessed at (b) 24 h (c) 48 h (d) 72 h with various concentrations. There were significant differences in the survival of SAS cells at the indicated VPA concentrations. After 72 h of treatment, the IC<sub>50</sub> of VPA was approximately 2 mM for SAS cells. Survival proportions for SAS cells showed statistically significant differences in values when compared with the vehicle control groups (<i>n</i> = 3; *<i>P</i> < 0.05; **<i>P</i> < 0.01; ***<i>P</i> < 0.001)