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  Indian J Med Microbiol
 

Figure 3: Time course of changes in the release of 5-hydroxytryptamine in the nucleus accumbens dialysate after repeated administration of methamphetamine, morphine or their combination in mice. The regimens of pretreatment with methamphetamine (0.75 mg/kg/day, MA0.75 and 2.5 mg/kg/day, MA2.5), morphine (5 mg/kg/day, M5) or their combination (MA0.75 + M5 and MA2.5 + M5) are as described in Figure 1. The administration of the respective drugs was given on day 5 as indicated by an arrow. Dialysate levels of 5-hydroxytryptamine in the nucleus accumbens were measured once every 20 min prior to and after treatment with drugs or saline. The combination of Methamphetamine and morphine signifi cantly increased 5-hydroxytryptamine levels compared with methamphetamine or morphine alone. Each experimental group included six mice. Data are expressed as a percentage (mean ± standard error of mean) of the respective basal values. Repeated measures analysis of variance followed by Dunnett's test was used to analyze the signifi cance of differences between treatments during the 120 min perfusion period in levels of 5-hydroxytryptamine (MA0.75 + M5 vs. MA0.75, *P < 0.01; MA2.5 + M5 vs. MA2.5, #P < 0.001)

Figure 3: Time course of changes in the release of 5-hydroxytryptamine in the nucleus accumbens dialysate after repeated administration of methamphetamine, morphine or their combination in mice. The regimens of pretreatment with methamphetamine (0.75 mg/kg/day, MA0.75 and 2.5 mg/kg/day, MA2.5), morphine (5 mg/kg/day, M5) or their combination (MA0.75 + M5 and MA2.5 + M5) are as described in Figure 1. The administration of the respective drugs was given on day 5 as indicated by an arrow. Dialysate levels of 5-hydroxytryptamine in the nucleus accumbens were measured once every 20 min prior to and after treatment with drugs or saline. The combination of Methamphetamine and morphine signifi cantly increased 5-hydroxytryptamine levels compared with methamphetamine or morphine alone. Each experimental group included six mice. Data are expressed as a percentage (mean ± standard error of mean) of the respective basal values. Repeated measures analysis of variance followed by Dunnett's test was used to analyze the signifi cance of differences between treatments during the 120 min perfusion period in levels of 5-hydroxytryptamine (MA0.75 + M5 vs. MA0.75, *<i>P</i> < 0.01; MA2.5 + M5 vs. MA2.5, <sup>#</sup><i>P</i> < 0.001)