• Users Online: 98
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Contacts Login 
ORIGINAL ARTICLE
Year : 2015  |  Volume : 35  |  Issue : 5  |  Page : 190-193

A study of the hematological profile of human immunodeficiency virus positive patients in coastal South Indian region


Department of Pathology, KMC, Manipal University, Mangalore, Karnataka, India

Correspondence Address:
Jyoti R Kini
Department of Pathology, KMC, Mangalore - 575 001, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1011-4564.167735

Rights and Permissions

Introduction: In India, approximately 6 million populations are affected by human immunodeficiency virus (HIV). Anemia and leukopenia, especially thrombocytopenia is seen commonly in HIV infections. Low CD4+ count and increased viral load are some of the factors associated with increased risk of thrombocytopenia. We analyzed the hematological profile in a group of 150 HIV infected patients. Materials and Methods: A retrospective and prospective study of medical records of 150 HIV positive patients at Clinical Pathology laboratory at our institution was done between August 1 st and October 15 th, 2011 using nonrandom sampling. Hemoglobin (Hb), hematocrit, red cell indices, total leukocyte and differential count, CD4+ and platelet count were noted. Results: Of the 150 patients, 40 (26.67%) were below age 10 and 98 (65.33%) in 21-50 years age group. Eighty-six (57.33%) were females. Hundred patients had anemia (Hb <12 g/dl) of which 58% were microcytic hypochromic (MCHC). Eighteen patients had leukopenia along with anemia. Total number of patients with low CD4 count (<200/μL) was 32 (21.33%) and all had hematological abnormalities, mostly anemias with few leukopenia and thrombocytopenias. All patients with pancytopenia had low CD4+ counts. Total number of patients with thrombocytopenia (<1.5 lacs/dl) was 20 (13.33%). Four patients (2.67%) had pancytopenia. Conclusions: MCHC anemia is the most common morphological variant of anemia. Leukopenia was found to be consistently associated with anemia. Thus, anemia and to a greater extent leukopenia are bad prognostic indicators of disease. Pancytopenia may herald a low CD4+ count.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2860    
    Printed51    
    Emailed1    
    PDF Downloaded291    
    Comments [Add]    
    Cited by others 2    

Recommend this journal