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CASE REPORT
Year : 2017  |  Volume : 37  |  Issue : 3  |  Page : 117-119

Gastrointestinal amyloidosis in a patient with systemic sclerosis


1 Department of Medicine, Division of Rheumatology, Immunology and Allergy, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
2 Department of Internal Medicine, Division of Gastroenterology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
3 Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China

Correspondence Address:
Tsung-Yun Hou
No. 325, Sec. 2, Cheng.Gong Road, Neihu 114, Taipei, Republic of China. Tel: +886. 2. 87923311#12609; Fax: +886. 2. 87927209
Republic of China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmedsci.jmedsci_64_16

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There were more than 90% of systemic sclerosis (SSc) patients developing gastrointestinal tract involvement with affecting esophagus mostly. However, a typical gastrointestinal manifestation may be not the only result of SSc. We described a 70-year-old female with SSc presented poor appetite, intermittent heartburn sensation, nausea, frequent sensation of abdominal fullness, and intermittent dull pain for 2 months. The esophagogastroduodenoscopy showed gastrointestinal as gastroesophageal reflux disease. The biopsy revealed amorphous material deposited in the vascular walls and apple-green birefringence in a polarization examination with Congo red staining which proved amyloidosis. The SSc patient with gastrointestinal involvement suggests to receive esophagogastroduodenoscopy, and a biopsy may be helpful to these patients to examine the possibility of secondary amyloidosis. These patients need more aggressively disease activity control.


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