• Users Online: 73
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Contacts Login 
ORIGINAL ARTICLE

Vitamin D supplementation in the prevention of recurrent acute respiratory tract infections in children aged <5 years


1 Department of Pharmacology, Krishna Institute of Medical Sciences (Deemed-to-be University), Karad, Maharashtra, India
2 Department of Pediatrics, Krishna Institute of Medical Sciences (Deemed-to-be University), Karad, Maharashtra, India

Correspondence Address:
Sujata Jadhav,
Department of Pharmacology, Krishna Institute of Medical Sciences (Deemed-to-be University), Karad, Maharashtra - 415 110
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmedsci.jmedsci_101_20

Background: Children with Vitamin D deficiency are at an increased risk for acute respiratory tract infections (ARTIs). Till now, few studies have been conducted on the use of Vitamin D against ARTIs, but the findings are conflicting and not conclusive. Aim: The aim was to study the effect of Vitamin D supplementation in the prevention of recurrent ARTIs in under-five children. Methods: In this prospective study, a total of 310 children aged between 1 and 5 years diagnosed with ARTI were included. They were randomized into two groups: Group A (oral Vitamin D 120,000 IU with standard treatment; n = 155) and Group B (placebo with standard treatment only; n = 155). Follow-up of the patient was done every month for a period of 6 months to document the recurrence of acute attacks of ARTI. R version 3.6.0 software was employed to analyze the data. Results: Twelve children (3.9%) in Group B were unable to follow-up, and hence, 143 were considered for statistical analyses in that group. Among the 298 children, 63.7% were males and majority (25.5%) of them were in the age group of 11–20 months. Cough (96%), fever (93%), and rhinitis (85.2%) were the commonly encountered symptoms. On day 4th (after Vitamin D supplementation), majority in Group A (40%) had recovered completely compared to Group B (5.6%). Within 5 days, Group A patients were 7 times (odds ratio: 6.97, Confidence interval: 3.5–13.8; P < 0.0001) more likely to have a high recovery rate compared to Group B patients. The proportion of patients with minimal attacks (three or four) of ARTI was significantly less in Group A (7.7%) compared to Group B (32.4%; P < 0.001). Conclusions: Children with Vitamin D supplementation had better and rapid recovery from ARTIs and reduced frequency of ARTI attacks.


 

  Search Pubmed for
 
    -  Jadhav S
    -  Khanwelkar C
    -  Jadhav A
    -  Seshla S
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed79    
    PDF Downloaded5    

Recommend this journal