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  Indian J Med Microbiol
 

Figure 4: The changes of blood flow in (a) tongue, (b) palm, (c) sole, and (d) abdomen at the end of experiment (at 24 h) in wild-type or SPAK knockout mice treated with lipopolysaccharide. Depicted are SPAK+/+ mice that received saline (SPAK+/+ + vehicle, n = 10) or lipopolysaccharide (SPAK+/+ + lipopolysaccharide, n = 9), SPAK+/-mice that received saline (SPAK+/- + vehicle, n = 12) or lipopolysaccharide (SPAK+/- + lipopolysaccharide, n = 12), and SPAK-/- mice that received saline (SPAK-/- + vehicle, n = 5) or lipopolysaccharide (SPAK-/- + lipopolysaccharide, n = 7). Data are expressed as mean ± standard error of mean *P < 0.05, all versus SPAK+/+ + vehicle mice; #P < 0.05, without versus with SPAK in lipopolysaccharide mice. SPAK = STE20/SPS1-realted proline/alanine-rich kinase

Figure 4: The changes of blood flow in (a) tongue, (b) palm, (c) sole, and (d) abdomen at the end of experiment (at 24 h) in wild-type or SPAK knockout mice treated with lipopolysaccharide. Depicted are SPAK<sup>+/+</sup> mice that received saline (SPAK<sup>+/+</sup> + vehicle, <i>n</i> = 10) or lipopolysaccharide (SPAK<sup>+/+</sup> + lipopolysaccharide, <i>n</i> = 9), SPAK<sup>+/-</sup>mice that received saline (SPAK<sup>+/-</sup> + vehicle, <i>n</i> = 12) or lipopolysaccharide (SPAK<sup>+/-</sup> + lipopolysaccharide, <i>n</i> = 12), and SPAK<sup>-/-</sup> mice that received saline (SPAK<sup>-/-</sup> + vehicle, <i>n</i> = 5) or lipopolysaccharide (SPAK<sup>-/-</sup> + lipopolysaccharide, <i>n</i> = 7). Data are expressed as mean ± standard error of mean *<i>P</i> < 0.05, all versus SPAK<sup>+/+</sup> + vehicle mice; <sup>#</sup><i>P</i> < 0.05, without versus with SPAK in lipopolysaccharide mice. SPAK = STE20/SPS1-realted proline/alanine-rich kinase